Shannen Doherty says that her cancer has worsened and "might have actually gone out of the lymph nodes." The 45-year-old actress told Entertainment Tonight that "we are doing chemo, and then after chemo, I'll do radiation." She had a double mastectomy in May, she said. "The unknown is always the scariest part," she continued. "Is the chemo going to work? Is the radiation going to work? You know, am I going to have to go through this again, or am I going to get secondary cancer? Everything else is manageable. Pain is manageable, you know living without a breast is manageable, it's the worry of your future and how your future is going to affect the people that you love."