He may not be his own drug, but Uncle Jesse will do: E! Online says CBS President Les Moonves has met with actor John Stamos to discuss replacing Charlie Sheen as the main character on Two and a Half Men. E’s source says Stamos would play a new character. What does Charlie Sheen think of this? Stamos is a “tragic joke,” Sheen tells TMZ. "If they do that then they deserve their failures and the follies." UPDATE: Stamos tweeted: "contrary to the rumors, i am not replacing charlie sheen on two and half men. however, martin sheen has asked me to be his son."