The beloved novel, A Confederacy of Dunces, is said to be headed for Hollywood’s silver screen, with Zach Galifianakis set to star as Reilly. The film will reportedly be directed by Muppets director James Bobin and is being produced by Scott Rudin and financed by Paramount Pictures. The movie is said to be headed to New Orleans for shooting. The news comes 30 years after John Belushi was tapped to play the role before dying of a drug overdose. Attempts in 1994, 1997, and 2007 all fell flat, as well.