Law-enforcement agencies "working closer than ever before" have launched drug-trafficking charges against 43 people in the U.S. and Mexico, including several suspected cartel leaders. Attorney General Eric Holder Jr. appeared alongside U.S. Attorneys Patrick Fitzgerald and Benton Campbell to announce court filings that Campbell said were "among the most significant drug-conspiracy charges ever returned" in his home state of New York. Fitzgerald said the suspects had used "practically every means of transportation imaginable" for smuggling cocaine and heroin into the U.S., including planes, submarines, trains, fishing vessels, and tractor-trailers. Among the indictments unsealed Thursday were Joaquin "El Chapo" Guzman-Loera, Ismael "El Mayo" Zambada-Garcia and Arturo Beltran-Leyva. El Chapo's notoriety precedes him: He was No. 701 in this year's Forbes magazine list of the richest people in the world, with an estimated net worth of $1 billion. He has been indicted before but has repeatedly eluded capture.