In a sign that the White House is getting increasingly nervous about the 2010 races, Vice President Joe Biden said at a fundraiser Monday that if Democrats lose seats in traditionally Republican districts it will mean "the end of the road" for the president's agenda. “If they take them back, this the end of the road for what Barack and I are trying to do,” the vice president said. The Republicans need to win 40 seats to take back control of the House. Almost 50 Democrats hold seats in districts that went to Sen. John McCain in the last election. The White House has been aggressively involved in state-level elections, The Washington Post reports, led by Chief of Staff Rahm Emanuel. President Obama caught some criticism when it was revealed that his aides were encouraging Gov. David Paterson to stay out of the race for the good of Democrats.